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J Exp Med. 1989 Jun 1;169(6):2263-8. doi: 10.1084/jem.169.6.2263.
2
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10
Analysis of the HLA-DR gene frequencies in Japanese cases of juveniles rheumatoid arthritis and rheumatoid arthritis by oligonucleotide DNA typing.通过寡核苷酸DNA分型分析日本青少年类风湿性关节炎和类风湿性关节炎病例中的HLA - DR基因频率。
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本文引用的文献

1
HLA and rheumatoid arthritis in the Japanese.日本人的 HLA 与类风湿关节炎
Arthritis Rheum. 1981 May;24(5):722-5. doi: 10.1002/art.1780240516.
2
HLA-DR antigens in rheumatoid arthritis in North India.印度北部类风湿关节炎中的人类白细胞抗原-DR抗原
Tissue Antigens. 1982 Oct;20(4):300-2. doi: 10.1111/j.1399-0039.1982.tb00360.x.
3
Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis.HLA-Aw31和HLA-DR1与成人类风湿性关节炎的关联。
Ann Rheum Dis. 1982 Aug;41(4):403-4. doi: 10.1136/ard.41.4.403.
4
HLA-DR4 in Negro and Mexican rheumatoid arthritis patients.黑人及墨西哥类风湿性关节炎患者中的HLA - DR4
J Rheumatol. 1981 Sep-Oct;8(5):804-7.
5
HLA DR4 and rheumatoid arthritis in Japanese people.日本人群中的人类白细胞抗原DR4与类风湿关节炎
Ann Rheum Dis. 1981 Jun;40(3):299-302. doi: 10.1136/ard.40.3.299.
6
Association of HLA-DRw4 with rheumatoid arthritis in black and white patients.HLA-DRw4与黑种人和白种人类风湿关节炎的关联。
Arthritis Rheum. 1980 Nov;23(11):1241-5. doi: 10.1002/art.1780231102.
7
Rheumatoid arthritis in a Chippewa band. II. Field study with clinical serologic and HLA-D correlations.齐佩瓦部落的类风湿性关节炎。II. 临床血清学及HLA-D相关性的现场研究。
J Rheumatol. 1983 Feb;10(1):28-32.
8
Serological and cellular definition of a new HLA-DR associated determinant, MC1, and its association with rheumatoid arthritis.一种新的HLA - DR相关决定簇MC1的血清学和细胞定义及其与类风湿性关节炎的关联。
Hum Immunol. 1984 Jul;10(3):165-76. doi: 10.1016/0198-8859(84)90037-5.
9
Sequence polymorphism of HLA DR beta 1 alleles relating to T-cell-recognized determinants.与T细胞识别决定簇相关的HLA DRβ1等位基因的序列多态性。
Nature. 1985;317(6033):166-8. doi: 10.1038/317166a0.
10
Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes.用等位基因特异性寡核苷酸探针分析酶促扩增的β-珠蛋白和HLA-DQα DNA。
Nature. 1986;324(6093):163-6. doi: 10.1038/324163a0.

与类风湿性关节炎易感性相关的HLA - DRB链的推测氨基酸序列。

Putative amino acid sequence of HLA-DRB chain contributing to rheumatoid arthritis susceptibility.

作者信息

Watanabe Y, Tokunaga K, Matsuki K, Takeuchi F, Matsuta K, Maeda H, Omoto K, Juji T

机构信息

Department of Anthropology, Faculty of Science, University of Tokyo, Japan.

出版信息

J Exp Med. 1989 Jun 1;169(6):2263-8. doi: 10.1084/jem.169.6.2263.

DOI:10.1084/jem.169.6.2263
PMID:2732676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189339/
Abstract

The association between HLA-DR4 and rheumatoid arthritis (RA) has been established in many ethnic groups. To clarify the determinant of susceptibility to RA, a polymorphic segment of the HLA-DRB gene was amplified in vitro by polymerase chain reaction and analyzed with oligonucleotide probes specific for the HLA-DR4 DNA sequences. A particular sequence encoding amino acids Gln70-Arg71-Arg72-Ala73-Ala74 showed a strong association with RA (p less than 0.005, relative risk 6.0). This amino acid sequence occurs in the DRB molecules with three RA-associated specificities, DR4/Dw14, DR4/Dw15, and DR1. DR4/Dw4, which is common in Caucasian RA patients, has a strikingly similar amino acid sequence Gln70-Lys71-Arg72-Ala73-Ala74 in terms of polarity and charge profiles. Other RA nonassociated sequences differ from this sequence by at least one amino acid substitution that causes the change of the net charge. The composition of amino acid residues at the positions 70-74 may play a crucial role in the pathogenesis of RA.

摘要

HLA - DR4与类风湿关节炎（RA）之间的关联已在许多种族群体中得到证实。为了阐明RA易感性的决定因素，通过聚合酶链反应在体外扩增了HLA - DRB基因的一个多态性片段，并用针对HLA - DR4 DNA序列的寡核苷酸探针进行分析。一个编码氨基酸Gln70 - Arg71 - Arg72 - Ala73 - Ala74的特定序列与RA呈现出强关联（p小于0.005，相对风险为6.0）。该氨基酸序列存在于具有三种与RA相关特异性的DRB分子中，即DR4/Dw14、DR4/Dw15和DR1。在白种人RA患者中常见的DR4/Dw4，在极性和电荷分布方面具有惊人相似的氨基酸序列Gln70 - Lys71 - Arg72 - Ala73 - Ala74。其他与RA不相关的序列与该序列至少有一个氨基酸取代不同，这导致了净电荷的变化。70 - 74位氨基酸残基的组成可能在RA的发病机制中起关键作用。