Lepage V, Alcalay D, Douay C, Mallet C, Loiseau P, Degos L, Colombani M, Colombani J
Tissue Antigens. 1985 Feb;25(2):96-102. doi: 10.1111/j.1399-0039.1985.tb00421.x.
Evidence for a new HLA class II specificity is presented. It is recognized by LE serum, which reacts with most DR1 and/or DR4 individuals (r = 0.86). Its frequency in the French population is 0.33. Absorption-elution experiments showed that the serum reactivity was not due to a mixture of anti-DR1 and anti-DR4 antibodies, but to a single antibody population which could be absorbed on and eluted from both DR1(+) or DR4(+) cells. LE specificity seemed to be expressed on DR but not on DQ molecules since the serum reacted with and could be absorbed by DR+,DQw- cells; it did not react with a DR-,DQw+ mutant cell, but did react with the DR+,DQw+ parental cell. The relationship between LE specificity and MC1 and Te23 specificities remains to be determined.
本文提供了一种新的人类白细胞抗原（HLA）Ⅱ类特异性的证据。它可被LE血清识别，该血清与大多数DR1和/或DR4个体发生反应（r = 0.86）。其在法国人群中的频率为0.33。吸收 - 洗脱实验表明，血清反应性并非由于抗DR1和抗DR4抗体的混合物，而是由于单一抗体群体，该群体可在DR1(+)或DR4(+)细胞上吸收和洗脱。LE特异性似乎在DR分子上表达，而不在DQ分子上表达，因为该血清与DR +、DQw - 细胞发生反应并可被其吸收；它不与DR -、DQw + 突变细胞反应，但与DR +、DQw + 亲代细胞反应。LE特异性与MC1和Te23特异性之间的关系仍有待确定。
