Haemoglobin A1c in pregnant diabetic patients at delivery and haemoglobin F1 in cord blood from their newborns.

Haemoglobin A1c has been measured in diabetic and non-diabetic pregnant women at delivery as well as haemoglobin F adducts in paired cord blood of their infants. Haemoglobin A1c and haemoglobin F adduct estimates covariate in a group of diabetic and non-diabetic pregnant women/infants studied by ion exchange chromatography, but not when studied by isoelectric focusing. Haemoglobin A1c and birth weight ratio covariate when haemoglobin A1c is determined by isoelectric focusing but not when estimated by ion exchange chromatography. Similar results appear from the studies of others indicating that mothers' haemoglobin A1c covariates with cord blood haemoglobin F adducts and with the birth weight ratio, though correlation is scant because of extensive and efficient control of diabetic pregnant women.