Bartkowski S B, Panaś M, Wilczańska H, Dubiel-Bigaj M
Am J Surg. 1984 Sep;148(3):362-6. doi: 10.1016/0002-9610(84)90472-0.
Twenty patients with primary malignant melanoma of the oral cavity have been described. They formed 3.9 percent of the total number of patients with malignant neoplasms of the oral cavity. The upper gingiva was most commonly affected. In this series, there were 14 male patients and 6 female patients who ranged in age from 26 to 80 years (average 58 years). The first symptom of melanoma was hyperpigmentation of the mucosa in 10 patients, tumor in 7, and pain in 3 edentulous patients with prostheses. Radical surgery was performed in 13 patients, followed by chemotherapy and radiotherapy in 9 cases. Only 1 patient survived 9 years. The remaining 12 died 11 to 18 months after radical treatment. Palliative therapy was applied in three patients, two patients were treated symptomatically, and two patients refused treatment. Early detection of melanoma is an indication for radical treatment and may increase the survival rate of patients with this disease, which is still very low.
本文描述了20例原发性口腔恶性黑色素瘤患者。他们占口腔恶性肿瘤患者总数的3.9%。上牙龈是最常受累的部位。在这个系列中，有14例男性患者和6例女性患者，年龄在26岁至80岁之间（平均58岁）。黑色素瘤的首发症状在10例患者中为黏膜色素沉着，7例为肿瘤，3例无牙佩戴假牙的患者为疼痛。13例患者接受了根治性手术，其中9例随后接受了化疗和放疗。只有1例患者存活了9年。其余12例在根治性治疗后11至18个月死亡。3例患者接受了姑息治疗，2例患者接受了对症治疗，2例患者拒绝治疗。黑色素瘤的早期发现是根治性治疗的指征，可能会提高这种疾病患者的生存率，而目前该疾病的生存率仍然很低。
