Barabás József, Suba Zsuzsanna, Szabó György, Ujpál Marta
Semmelweis Egyetem Arc-Allcsont-Szájsebészeti és Fogászati Klinika.
Fogorv Sz. 2006 Aug;99(4):149-52.
Malignant melanoma occurs only rarely as a primary tumour in the oral cavity, with an incidence of 1-2 percent. Oral melanomas are predominantly to be found in the hard and soft palate, and less often in the gingiva and mandible. Mucosal malignant melanomas are much more aggressive than those situated in the skin. In two-thirds of the cases the route of formation of the metastases is lymphogenic, and haematogenic in the remainder. The typical sites of the distant metastases are the skin, the lungs, the brain, the liver, and the bones. Metastatic malignant melanoma in the oral cavity, a rarity in the literature, is associated with a very poor prognosis. This paper reports on two cases in which an isolated distant metastasis developed in the oral cavity.
恶性黑色素瘤作为原发性肿瘤在口腔中极为罕见,发病率为1%-2%。口腔黑色素瘤主要见于硬腭和软腭,较少见于牙龈和下颌骨。黏膜恶性黑色素瘤比皮肤恶性黑色素瘤侵袭性更强。三分之二的病例转移途径为淋巴转移,其余为血行转移。远处转移的典型部位是皮肤、肺、脑、肝和骨。口腔转移性恶性黑色素瘤在文献中较为罕见,预后很差。本文报告两例在口腔出现孤立远处转移的病例。