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儿茶酚胺与大鼠子宫对雌二醇的水肿反应

Cactecholamines and the oedematous reaction to oestradiol in the rat uterus.

作者信息

Brandon J M

出版信息

Eur J Pharmacol. 1978 Jan 15;47(2):235-8. doi: 10.1016/0014-2999(78)90396-5.

DOI:10.1016/0014-2999(78)90396-5
PMID:620685
Abstract

The effect of catecholamines on the 4 h oedematous reaction to estradiol in the immature rat uterus was investigated. Isoprenaline was found to augment the reaction to suboptimal doses of estradiol (0.25--0.5 microgram/kg. This effect was reversed by d,l-propranolol. Adrenaline and noradrenaline were found to inhibit the reaction to oestradiol 2 microgram/kg. The effect of adrenaline was reversed by phenotalmine.

摘要

研究了儿茶酚胺对未成熟大鼠子宫中雌二醇所致4小时水肿反应的影响。发现异丙肾上腺素可增强对次优剂量雌二醇(0.25 - 0.5微克/千克)的反应。该作用可被d,l-普萘洛尔逆转。发现肾上腺素和去甲肾上腺素可抑制对2微克/千克雌二醇的反应。肾上腺素的作用可被酚妥拉明逆转。

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