Praet M M, Roels H J
Exp Pathol. 1984;26(1):3-14. doi: 10.1016/s0232-1513(84)80063-8.
A sequential, histologic analysis of the livers of male albino rats chronically fed the hepatocarcinogen thioacetamide (TAA) is performed after one, two, three, four, eight and twelve months of treatment. Liver cell alterations present after one, two and three months consist of centrolobular liver cell degeneration and oval cell proliferation. After 8 months of TAA treatment, a variety of benign tumors (cystadenomas, angiomas, cholangiomas) is observed. From the 12th month all experimental animals develop cholangiocarcinomas. Pulmonary metastases are discovered after 15 months. The role of the oval cells in relation to the later appearing cholangiocarcinoma is discussed. A review of literature is given.
对长期喂食肝癌诱发剂硫代乙酰胺（TAA）的雄性白化大鼠的肝脏进行组织学分析，分别在治疗1个月、2个月、3个月、4个月、8个月和12个月后进行。1个月、2个月和3个月后出现的肝细胞改变包括中央小叶肝细胞变性和卵圆细胞增殖。TAA治疗8个月后，观察到多种良性肿瘤（囊腺瘤、血管瘤、胆管瘤）。从第12个月起，所有实验动物均发生胆管癌。15个月后发现肺转移。讨论了卵圆细胞与后期出现的胆管癌的关系，并给出了文献综述。
