Sangster B, de Groot G, Loeber J G, Derks H J, Krajnc E I, Savelkoul T J
Hum Toxicol. 1984 Feb;3(1):7-21. doi: 10.1177/0960327184003001021.
Urine was collected from 289 inhabitants of a cadmium-polluted quarter of Stadskanaal. The excretion of cadmium, protein, beta-2-microglobulin and glucose were determined. After being divided according to sex and to smoking habits, the results of the inhabitants were compared with those of 293 controls. In inhabitants as well as controls, cadmium excretion was age-dependent. Cadmium excretion in females increased faster with age than in males. In male-smoker controls, cadmium excretion was significantly higher (p less than 0.001) than in male-non-smoker controls. In male-non-smoker inhabitants, cadmium excretion (p = 0.05), protein excretion (p less than 0.01) and glucose excretion (p less than 0.01) were significantly higher than in corresponding controls. In male-smoker inhabitants, protein excretion (p less than 0.01) and glucose excretion (0.01 less than p less than 0.05) were significantly higher than in corresponding controls. In female-non-smoker inhabitants glucose excretion was significantly higher (0.01 less than p less than 0.05) than in corresponding controls. For some categories, living in the polluted area was associated with an increased cadmium excretion in urine and a slight difference in renal function, possibly related to a difference in cadmium body burden. It was concluded that, considering the actual values of each parameter, the observed differences were not relevant in terms of potential health hazards.
从斯塔德斯卡纳尔一个镉污染区的289名居民中收集尿液。测定了镉、蛋白质、β-2-微球蛋白和葡萄糖的排泄量。根据性别和吸烟习惯进行分组后，将这些居民的结果与293名对照者的结果进行比较。在居民和对照者中，镉排泄量均与年龄有关。女性镉排泄量随年龄增长的速度比男性快。在男性吸烟对照者中，镉排泄量显著高于男性非吸烟对照者（p<0.001）。在男性非吸烟居民中，镉排泄量（p = 0.05）、蛋白质排泄量（p<0.01）和葡萄糖排泄量（p<0.01）显著高于相应的对照者。在男性吸烟居民中，蛋白质排泄量（p<0.01）和葡萄糖排泄量（0.01<p<0.05）显著高于相应的对照者。在女性非吸烟居民中，葡萄糖排泄量显著高于相应的对照者（0.01<p<0.05）。对于某些类别，生活在污染区与尿镉排泄增加以及肾功能的轻微差异有关，这可能与镉体内负荷的差异有关。得出的结论是，考虑到每个参数的实际值，观察到的差异在潜在健康危害方面并不相关。
