Canepa S, Horowitz R, Degenne D, Magnin G, Valat C, Bardos P
Immunol Lett. 1984;8(4):159-63. doi: 10.1016/0165-2478(84)90070-1.
Using monoclonal antibodies (OKT3, OKT4, OKT8) peripheral blood lymphocyte subsets were determined in 40 normal primiparous pregnant women and compared with those of 31 nonpregnant controls. In pregnant women plasma concentrations of estradiol, progesterone, human placental lactogen (HPL), beta subunit of human chorionic gonadotropin (beta HCG), and alpha-fetoprotein were measured by means of radioimmunoassay. We studied if correlations between peripheral lymphocyte subsets and plasma hormone levels might exist. We observed in pregnant women from 10 to 40 wk of amenorrhea a decrease in the percentage of OKT3 and OKT8 cells, and during the course of pregnancy an increase in the percentage of OKT4 cells. This increase inversely correlated with plasma beta HCG levels and directly correlated with plasma HPL levels.
使用单克隆抗体（OKT3、OKT4、OKT8）对40名正常初产妇孕妇的外周血淋巴细胞亚群进行了测定，并与31名非孕妇对照组进行了比较。通过放射免疫分析法测定了孕妇血浆中雌二醇、孕酮、人胎盘催乳素（HPL）、人绒毛膜促性腺激素β亚基（β-HCG）和甲胎蛋白的浓度。我们研究了外周淋巴细胞亚群与血浆激素水平之间是否可能存在相关性。我们观察到，在闭经10至40周的孕妇中，OKT3和OKT8细胞的百分比降低，而在妊娠过程中，OKT4细胞的百分比增加。这种增加与血浆β-HCG水平呈负相关，与血浆HPL水平呈正相关。
