Boos R, Rabe D, Schmidt W
Z Geburtshilfe Perinatol. 1984 Sep-Oct;188(5):244-7.
With reference to a case of occipital encephalocele associated with iniencephaly diagnosed by ultrasonography in the 20th week of pregnancy, the diagnostic problems of craniospinal defects, factors influencing prognosis and clinical consequences are described. Even when results of biochemical tests are negative, minute neural canal defects can be diagnosed early by ultrasonography. In the authors' opinion an ultrasonographic diagnosis of encephalocele represents an indication for termination of pregnancy, in view of the poor prognosis.
参考一例妊娠20周时经超声诊断为枕部脑膨出合并脊柱裂畸形的病例，描述了颅脊柱缺损的诊断问题、影响预后的因素及临床后果。即使生化检查结果为阴性，微小的神经管缺损也可通过超声早期诊断。作者认为，鉴于预后不良，超声诊断脑膨出是终止妊娠的指征。
