Klemp P, Bojsen J
J Invest Dermatol. 1986 Feb;86(2):109-14. doi: 10.1111/1523-1747.ep12284077.
The accuracy of the 133Xe washout method and the validity of newly developed cadmium telluride CdTe(Cl) minisemiconductor detectors were estimated by performing comparative, simultaneous measurements of both cutaneous (CBF) and subcutaneous (SBF) blood flow using 2 conventional scintillation sodium iodide NaI(Tl) and CdTe(Cl) detectors over the same radioactive depot in each of 10 individuals. The accuracy of the 133Xe washout method was found to be 13-15% (C.V.) for the CBF measurements and 9-12% (C.V.) for the SBF measurements. The CdTe(Cl) detectors, which have a weight of 20 g and were attached directly over the radioactive depot, may replace stationary NaI(Tl) detectors placed 20 cm from the depot for measurements of both CBF and SBF. Two CdTe(Cl) detectors were used for estimations of the local variation in CBF and SBF within a distance of 5 cm in normal skin of 10 individuals. The C.V. was 7% for the CBF measurements and 18% for the SBF measurements. Measurements of CBF and SBF were performed in 6 psoriatic patients who, after about 1 week of antipsoriatic treatment with beech tar, developed typical Woronoff rings. The local CBF differed significantly from the center of psoriatic plaques to the margin, in the Woronoff ring, and in nonlesional skin. In contrast, SBF was remarkably equal within the plaque and in the Woronoff ring. The color of the Woronoff ring cannot be ascribed to a local cutaneous vasoconstriction. Cutaneous blood flow in chronic stable, lesional psoriatic skin was significantly lower than previously published values for active lesional psoriatic skin, but significantly higher than CBF in normal individuals. Measurements of CBF in tetrahydrofurfuryl nicotinic acid (Trafuril)-treated skin showed higher values than measurements of CBF in the postischemic hyperemia period both in normal and in lesional psoriatic skin. Trafuril induced a significant increase of CBF in both lesional and nonlesional skin. The high CBF rates in lesional psoriatic skin are not due to a maximally, passively dilated vascular bed.
通过使用2个传统的碘化钠NaI(Tl)闪烁探测器和碲化镉CdTe(Cl)探测器，在10名个体的每个相同放射性储库上同时进行皮肤（CBF）和皮下（SBF）血流的比较测量，评估了133Xe洗脱法的准确性和新开发的碲化镉CdTe(Cl)微型半导体探测器的有效性。发现133Xe洗脱法在测量CBF时的准确性为13 - 15%（变异系数），测量SBF时为9 - 12%（变异系数）。重量为20克且直接附着在放射性储库上方的CdTe(Cl)探测器，可替代放置在距储库20厘米处的固定NaI(Tl)探测器来测量CBF和SBF。使用2个CdTe(Cl)探测器估计10名个体正常皮肤中5厘米距离内CBF和SBF的局部变化。测量CBF时变异系数为7%，测量SBF时为18%。对6名银屑病患者进行了CBF和SBF测量，这些患者在用山毛榉焦油进行约1周的抗银屑病治疗后出现了典型的Woronoff环。银屑病斑块中心到边缘、Woronoff环以及非病变皮肤处的局部CBF存在显著差异。相比之下，斑块内和Woronoff环内的SBF非常相等。Woronoff环的颜色不能归因于局部皮肤血管收缩。慢性稳定期病变银屑病皮肤的皮肤血流显著低于先前发表的活动期病变银屑病皮肤的值，但显著高于正常个体的CBF。在四氢糠基烟酸（Trafuril）处理的皮肤中测量CBF显示，无论是正常皮肤还是病变银屑病皮肤，其值都高于缺血后充血期的CBF测量值。Trafuril可使病变皮肤和非病变皮肤的CBF显著增加。病变银屑病皮肤中的高CBF率并非由于血管床最大程度地被动扩张所致。
