Klemp P
J Invest Dermatol. 1985 Aug;85(2):175-8. doi: 10.1111/1523-1747.ep12276617.
Local regulation of the doubled subcutaneous blood flow (SBF) rates in psoriatic lesional skin was studied in 8 patients using a traumatic epicutaneous 133Xe labeling washout technique. Venous stasis of 40 mm Hg induced a significant reduction in the SBF (-34%, p less than 0.01), i.e., a normal vasoconstrictor response. Limb elevation of 40 cm above heart level induced no statistical changes in the SBF (p = 0.50), i.e., a normal local autoregulation response. This indicates normal, local regulation mechanisms of SBF in psoriasis. In another 8 patients, the effect on SBF of a 4-week antipsoriatic treatment with tar was studied in lesional and symmetrically nonlesional skin areas. One patient was clear of psoriasis on day 22, and was followed only to that time. The mean pretreatment SBF in lesional skin areas was 3.87 +/- SD 0.78 ml X (100 g X min)-1, which was not statistically different from measurements on days 3, 7, 14, and 21 after treatment had started. Between day 21 and day 28, the SBF decreased significantly to 3.38 +/- SD 0.78 ml X (100 g X min)-1, p less than 0.05. The difference between the pretreatment SBF and SBF at the end of treatment was statistically significant, p less than 0.05. The changes in SBF in symmetrically nonlesional skin areas were statistically nonsignificant during the period of treatment. Pretreatment SBF was 2.60 +/- SD 1.08 (N = 8), and on day 28 was 1.91 +/- SD 0.74 ml X (100 g X min)-1 (N = 7). However, the tendency of a decreasing SBF at the end of treatment was a clear trend, since SBF in 6 of 7 patients decreased during the third week and in the patient who was discharged on day 22, a decrease in the SBF was observed on days 14 and 21. The week-to-week changes in the SBF of lesional and nonlesional skin sites were parallel, r = 0.93, p less than 0.02. The decrease in SBF in psoriatics during successful antipsoriatic treatment might be a secondary thermoregulatory phenomenon due to a decreasing cutaneous blood flow.
采用创伤性表皮133Xe标记洗脱技术，对8例患者银屑病皮损处皮肤皮下血流（SBF）速率加倍的局部调节进行了研究。40 mmHg的静脉淤滞导致SBF显著降低（-34%，p<0.01），即正常的血管收缩反应。肢体抬高至心脏水平以上40 cm时，SBF无统计学变化（p = 0.50），即正常的局部自动调节反应。这表明银屑病中SBF的局部调节机制正常。在另外8例患者中，研究了焦油抗银屑病治疗4周对皮损及对称非皮损皮肤区域SBF的影响。1例患者在第22天银屑病消退，仅随访至该时间点。皮损皮肤区域治疗前SBF的平均值为3.87±标准差0.78 ml×(100 g×min)-1，与治疗开始后第3、7、14和21天的测量值无统计学差异。在第21天至第28天之间，SBF显著降至3.38±标准差0.78 ml×(100 g×min)-1，p<0.05。治疗前SBF与治疗结束时SBF的差异具有统计学意义，p<0.05。在治疗期间，对称非皮损皮肤区域的SBF变化无统计学意义。治疗前SBF为2.60±标准差1.08（N = 8），第28天为1.91±标准差0.74 ml×(100 g×min)-1（N = 7）。然而，治疗结束时SBF下降的趋势很明显，因为7例患者中有6例在第三周SBF下降，在第22天出院的患者中，在第14天和第21天观察到SBF下降。皮损和非皮损皮肤部位SBF的每周变化是平行的，r = 0.93，p<0.02。在成功的抗银屑病治疗期间，银屑病患者SBF的降低可能是由于皮肤血流量减少导致的继发性体温调节现象。
