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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Prioux-Guyonneau M, Mocaër-Cretet E, Redjimi-Hafsi F, Jacquot C

Gen Pharmacol. 1982;13(3):251-4. doi: 10.1016/0306-3623(82)90097-0.

5-hydroxytryptamine (5-HT) level was measured in hypothalamus, striatum and the rest of the brain of rats exposed to 1800, 5200 and 7000 m simulated altitudes. 2. Moderate hypobaric hypoxia failed to modify 5-HT level, whereas severe hypoxia reduced the amine level by about 30%. 3. Treatment with a synthesis blocking agent (PCPA) revealed a dual effect of hypoxia on the 5-HT elimination. Increased elimination observed at 1800 m was attributed to the hypoxia-induced stress and the decrease (at 5200 and 7000 m) indicated the predominance of enzymatic inhibition. 4. It was assumed that tryptophan hydroxylase was more sensitive than monoamine oxidase to a high hypobaric hypoxia.

测定了暴露于模拟海拔1800米、5200米和7000米的大鼠下丘脑、纹状体及脑的其他部位的5-羟色胺（5-HT）水平。2. 中度低压缺氧未能改变5-HT水平，而重度缺氧使该胺水平降低约30%。3. 用合成阻断剂（PCPA）处理显示缺氧对5-HT消除有双重作用。在1800米处观察到的消除增加归因于缺氧诱导的应激，而（在5200米和7000米处）的降低表明酶抑制占主导。4. 据推测，色氨酸羟化酶比单胺氧化酶对高度低压缺氧更敏感。

Prioux-Guyonneau M, Mocaër-Cretet E, Redjimi-Hafsi F, Jacquot C

Gen Pharmacol. 1982;13(3):251-4. doi: 10.1016/0306-3623(82)90097-0.

5-hydroxytryptamine (5-HT) level was measured in hypothalamus, striatum and the rest of the brain of rats exposed to 1800, 5200 and 7000 m simulated altitudes. 2. Moderate hypobaric hypoxia failed to modify 5-HT level, whereas severe hypoxia reduced the amine level by about 30%. 3. Treatment with a synthesis blocking agent (PCPA) revealed a dual effect of hypoxia on the 5-HT elimination. Increased elimination observed at 1800 m was attributed to the hypoxia-induced stress and the decrease (at 5200 and 7000 m) indicated the predominance of enzymatic inhibition. 4. It was assumed that tryptophan hydroxylase was more sensitive than monoamine oxidase to a high hypobaric hypoxia.

测定了暴露于模拟海拔1800米、5200米和7000米的大鼠下丘脑、纹状体及脑的其他部位的5-羟色胺（5-HT）水平。2. 中度低压缺氧未能改变5-HT水平，而重度缺氧使该胺水平降低约30%。3. 用合成阻断剂（PCPA）处理显示缺氧对5-HT消除有双重作用。在1800米处观察到的消除增加归因于缺氧诱导的应激，而（在5200米和7000米处）的降低表明酶抑制占主导。4. 据推测，色氨酸羟化酶比单胺氧化酶对高度低压缺氧更敏感。