Mocaër-Cretet E, Prioux-Guyonneau M, Redjimi F, Cohen Y, Jacquot C
Naunyn Schmiedebergs Arch Pharmacol. 1984 Jul;326(4):287-90. doi: 10.1007/BF00501431.
The effects of tabernanthine on serotonin (5-HT) levels were determined in several brain areas of rats exposed to various simulated altitudes (1800, 5200, 7000 m). The 5-HT synthesis inhibitor, para-chlorophenylalanine (PCPA), was used to dissociate the effects occurring at synthesis and release levels. Tabernanthine antagonized the decrease in hypothalamic 5-HT levels induced by a 7000 m hypoxia and also suppressed the decrease in PCPA-induced depletion observed at 5200 and 7000 m in the hypothalamus, the striatum and the rest of the brain. It was assumed that tabernanthine stimulates different steps of 5-HT metabolism. These effects, revealed by hypoxia, are related to other peripheral and central properties of this drug.
在暴露于不同模拟海拔高度（1800米、5200米、7000米）的大鼠的多个脑区中，测定了利血胺对血清素（5-羟色胺，5-HT）水平的影响。使用5-羟色胺合成抑制剂对氯苯丙氨酸（PCPA）来区分在合成和释放水平上发生的影响。利血胺拮抗了7000米低氧诱导的下丘脑5-羟色胺水平的降低，并且还抑制了在5200米和7000米时，下丘脑、纹状体及脑的其他部位中观察到的PCPA诱导的耗竭的降低。据推测，利血胺刺激5-羟色胺代谢的不同步骤。低氧所揭示的这些效应与该药物的其他外周和中枢特性有关。
