标记物(X)(q28)在淋巴母细胞系中的表达。
Expression of the marker (X) (q28) in lymphoblastoid cell lines.
作者信息
Jacobs P A, Hunt P A, Mayer M, Wang J C, Boss G R, Erbe R W
出版信息
Am J Hum Genet. 1982 Jul;34(4):552-7.
Abstract
The marker(X)(q28) chromosome associated with one type of X-linked mental retardation has been demonstrated in lymphoblastoid cell lines established from affected individuals. The mar(x) can reliably and repeatedly be seen by the addition of FUdR to the cultures for 24 hrs prior to harvest. This simple technique provides an excellent in vitro experimental test system for investigation of the mar(X).
摘要
与一种X连锁智力迟钝相关的标记(X)(q28)染色体已在从受影响个体建立的淋巴母细胞系中得到证实。通过在收获前24小时向培养物中添加氟尿苷(FUdR)，可以可靠且重复地观察到mar(x)。这种简单的技术为研究mar(X)提供了一个出色的体外实验测试系统。
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