耐头孢噻吩肠杆菌科细菌和铜绿假单胞菌对阿米卡星及某些新型β-内酰胺类药物的体外敏感性
In vitro susceptibility of cephalothin-resistant Enterobacteriaceae and Pseudomonas aeruginosa to Amikacin and selected new beta-lactam agents.
作者信息
McNamara B T, Meyer R D, Pasiecznik K A
出版信息
Antimicrob Agents Chemother. 1982 May;21(5):753-7. doi: 10.1128/AAC.21.5.753.
Abstract
Amikacin was evaluated in vitro by agar dilution testing against 148 different clinical isolates of cephalothin-resistant Enterobacteriaceae and Pseudomonas aeruginosa in parallel with cephalothin, cefoxitin, moxalactam, N-formimidoyl thienamycin, ceftriaxone, and cefmenoxime. Cefsulodin was also evaluated against 39 isolates of P. aeruginosa. More than 80% of all isolates tested were also gentamicin resistant, as determined by disk testing. Moxalactam and amikacin had comparable high activities against Proteus species, Escherichia coli, Serratia species, and Providencia species, and both amikacin and N-formimidoyl thienamycin had comparably high activities against the Klebsiella-Enterobacter group. N-Formimidoyl thienamycin was the most active agent against P. aeruginosa, followed by cefsulodin and amikacin.
摘要
采用琼脂稀释法对148株耐头孢噻吩的肠杆菌科细菌和铜绿假单胞菌临床分离株进行体外药敏试验，评估阿米卡星与头孢噻吩、头孢西丁、莫西沙星、N-甲酰亚胺硫霉素、头孢曲松和头孢甲肟的抗菌活性。同时，采用头孢磺啶对39株铜绿假单胞菌进行药敏试验。通过纸片扩散法检测发现，超过80%的受试菌株对庆大霉素耐药。莫西沙星和阿米卡星对变形杆菌属、大肠杆菌、沙雷氏菌属和普罗威登斯菌属具有相当高的活性，阿米卡星和N-甲酰亚胺硫霉素对克雷伯菌-肠杆菌属具有相当高的活性。N-甲酰亚胺硫霉素是对铜绿假单胞菌活性最高的药物，其次是头孢磺啶和阿米卡星。
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