所选β-内酰胺类和氨基糖苷类抗生素对头孢噻吩耐药肠杆菌科细菌的抗菌活性
Antibacterial activity of selected beta-lactam and aminoglycoside antibiotics against cephalothin-resistant Enterobacteriaceae.
作者信息
Lewis R P, Meyer R D, Kraus L L
出版信息
Antimicrob Agents Chemother. 1976 May;9(5):780-6. doi: 10.1128/AAC.9.5.780.
The in vitro antibacterial activity of four beta-lactam antibiotics (cefatrizine [BL-S640], cefamandole, cefoxitin, and carbenicillin) and three aminoglycosides (amikacin, gentamicin, and tobramycin) was determined against 197 strains of cephalothin-resistant Enterobacteriaceae. Eighty strains were found to be gentamicin-sensitive, and 117 were found to be gentamicin-resistant. Carbenicillin was the most active beta-lactam antibiotic against gentamicin-sensitive Serratia marcescens and Enterobacter spp. Cefoxitin was the most active beta-lactam antibiotic against the remaining gentamicin-sensitive and -resistant Enterobacteriaceae, including Providencia stuartii and indole-positive Proteus spp. Cefatrizine exhibited little activity against the organisms studied. Cefamandole was less active than cefoxitin and carbenicillin. Amikacin was the most effective agent in vitro. With the exception of S. marcescens, cefoxitin appeared to be the next most promising agent in vitro against gentamicin- and cephalothin-resistant Enterobacteriaceae.
测定了四种β-内酰胺类抗生素（头孢瑞丁[BL-S640]、头孢孟多、头孢西丁和羧苄青霉素）和三种氨基糖苷类抗生素（阿米卡星、庆大霉素和妥布霉素）对197株耐头孢噻吩肠杆菌科细菌的体外抗菌活性。发现80株对庆大霉素敏感，117株对庆大霉素耐药。羧苄青霉素是对庆大霉素敏感的粘质沙雷菌和肠杆菌属最具活性的β-内酰胺类抗生素。头孢西丁是对其余庆大霉素敏感和耐药的肠杆菌科细菌（包括斯氏普罗威登斯菌和吲哚阳性变形杆菌属）最具活性的β-内酰胺类抗生素。头孢瑞丁对所研究的细菌几乎没有活性。头孢孟多的活性低于头孢西丁和羧苄青霉素。阿米卡星是体外最有效的药物。除粘质沙雷菌外，头孢西丁似乎是体外对抗庆大霉素和头孢噻吩耐药肠杆菌科细菌的下一个最有前景的药物。
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