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Suppression of the plaque-forming cell response by macrophages present in the normal rat spleen.

作者信息

Weiss A, Fitch F W

出版信息

J Immunol. 1978 Feb;120(2):357-9.

PMID:621383
Abstract

Depletion of phagocytic and/or adherent cells from normal rat spleen cell preparations permitted the generation of PFC to SRBC in vitro. Suppressive activity was associated with the presence of macrophages in the normal rat spleen, since irradiated unfractionated or irradiated adherent cells suppressed the PFC response of macrophage-depleted cells. Whereas depletion of macrophages from normal rat spleen cells permitted the PFC response to SRBC to occur, comparable treatment of mouse spleen cells eliminated the PFC response. These results are discussed in relation to the requirement for macrophages in the generation of PFC with rat cells in vitro.

摘要

相似文献

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Suppression of the plaque-forming cell response by macrophages present in the normal rat spleen.
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