Mongini P K, Rosenberg L T
J Immunol. 1978 Feb;120(2):459-62.
Acute infection with lactic dehydrogenase virus (LDV) causes a systemic alteration in lymphocyte circulatory patterns. Peripheral lymph nodes (LN) and spleens in acutely, but not chronically, infected mice retain a significantly greater proportion of injected 51Cr-labeled lymphocytes than the respective tissues in noninfected controls. This increase in lymphocyte localization in LN and spleen is dependent upon the dose of LDV injected and the timing of the infection. A relatively large dose of LDV (10(8) infectious units) causes an early but very transient increase in splenic lymphocyte localization accompanied by an early but prolonged increase in lymphocyte recovery in LN. Smaller doses of LDV cause more prolonged effects on splenic lymphocyte recovery and retarded effects on lymphocyte localization in LN. Increases in splenic recovery were always accompanied by decreases in hepatic recovery of lymphocytes. LDV-induced alteration in lymphocyte circulation may be responsible for many previously observed modifications of immune responses in LDV-infected mice.
乳酸脱氢酶病毒（LDV）的急性感染会导致淋巴细胞循环模式的全身性改变。急性感染而非慢性感染的小鼠的外周淋巴结（LN）和脾脏中，与未感染对照的相应组织相比，保留了显著更高比例的注射用51Cr标记的淋巴细胞。LN和脾脏中淋巴细胞定位的这种增加取决于注射的LDV剂量和感染时间。相对大剂量的LDV（10（8）个感染单位）会导致脾脏淋巴细胞定位早期但非常短暂的增加，同时伴有LN中淋巴细胞恢复的早期但持续时间较长的增加。较小剂量的LDV对脾脏淋巴细胞恢复有更持久的影响，对LN中淋巴细胞定位有延迟影响。脾脏恢复的增加总是伴随着肝脏中淋巴细胞恢复的减少。LDV诱导的淋巴细胞循环改变可能是LDV感染小鼠中许多先前观察到的免疫反应改变的原因。
