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1
Kinetics of the relation between suppressor and effector mechanisms in contact sensitivity in the guinea-pig.豚鼠接触性敏感中抑制与效应机制之间关系的动力学
Immunology. 1982 Sep;47(1):61-6.
2
Epicutaneous induction of hyporeactivity in contact sensitization. Demonstration of suppressor cells induced by contact with 2,4-dinitrothiocyanatebenzene.接触致敏中表皮诱导低反应性。接触2,4-二硝基硫氰酸苯诱导的抑制细胞的证明。
Immunology. 1975 Sep;29(3):517-25.
3
Central and peripheral action of suppressor cells in contact sensitivity in the guinea-pig.豚鼠接触性敏感中抑制细胞的中枢和外周作用。
Immunology. 1976 Apr;30(4):593-7.
4
Inhibition of the anti-receptor antibody response of contact sensitivity by interferon.干扰素对接触敏感性抗受体抗体反应的抑制作用。
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5
The effect of cyclophosphamide and irradiation on cells which suppress contact sensitivity in the mouse.环磷酰胺和辐射对小鼠中抑制接触敏感性的细胞的影响。
Clin Exp Immunol. 1976 Mar;23(3):554-61.
6
Local administration of cytostatic drug 4-hydroperoxy-cyclophosphamide (4-HPCY) facilitates cell-mediated immune reactions.细胞抑制药物4-氢过氧环磷酰胺（4-HPCY）的局部给药可促进细胞介导的免疫反应。
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7
Immune suppression with supraoptimal doses of antigen in contact sensitivity. I. Demonstration of suppressor cells and their sensitivity to cyclophosphamide.超最佳剂量抗原在接触性敏感反应中的免疫抑制作用。I. 抑制细胞的证实及其对环磷酰胺的敏感性
J Immunol. 1977 Jul;119(1):240-4.
8
Changes in lymphocyte subsets after treatment with cyclophosphamide and during the development of contact sensitivity in the guinea pig.环磷酰胺治疗后及豚鼠接触性敏感反应发生过程中淋巴细胞亚群的变化。
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9
Suppressor cells in antigenic competition in contact allergy in mice.小鼠接触性过敏中抗原竞争中的抑制细胞。
Immunology. 1978 Jun;34(6):981-7.
10
RRBC and EAC rosette formation after DNCB contact sensitization and cyclophosphamide treatment of guinea-pigs.二硝基氯苯接触致敏和环磷酰胺处理豚鼠后的红细胞玫瑰花结（RRBC）和红细胞抗体补体玫瑰花结（EAC）形成
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引用本文的文献

1
Sensitivity and subsequent "down regulation" of sensitivity induced by chlorocresol in guinea pigs.氯甲酚对豚鼠敏感性的影响以及随后诱导产生的敏感性“下调” 。
Arch Dermatol Res. 1985;277(2):84-7. doi: 10.1007/BF00414102.
2
Lymphocyte subsets in patients with compositae oleoresin dermatitis and increased UVA sensitivity during treatment with azathioprine.复方树脂皮炎患者的淋巴细胞亚群及硫唑嘌呤治疗期间UVA敏感性增加
Arch Dermatol Res. 1985;277(4):304-6. doi: 10.1007/BF00509085.

本文引用的文献

1
A HISTOLOGICAL AND AUTORADIOGRAPHIC STUDY OF LYMPH NODES DURING THE DEVELOPMENT OF CONTACT SENSITIVITY IN THE GUINEA-PIG.豚鼠接触性敏感发育过程中淋巴结的组织学与放射自显影研究
Br J Exp Pathol. 1965 Apr;46(2):147-54.
2
Suppression of delayed hypersensitivity to tuberculin by antigenic competition. A positive immunoregulatory mechanism sensitive to cyclophosphamide.抗原竞争对结核菌素迟发型超敏反应的抑制。一种对环磷酰胺敏感的阳性免疫调节机制。
Immunology. 1981 Apr;42(4):549-59.
3
The effect of cyclophosphamide and role suppressor cells in the desensitization of delayed hypersensitivity.环磷酰胺的作用及抑制细胞在迟发型超敏反应脱敏中的作用。
Immunology. 1981 May;43(1):191-6.
4
Selective depletion of lymphoid tissue by cyclophosphamide.用环磷酰胺选择性地消耗淋巴组织。
Clin Exp Immunol. 1972 Feb;10(2):285-96.
5
Cyclophosphamide inhibited B cell receptor regeneration as a basis for drug-induced tolerance;环磷酰胺抑制B细胞受体再生作为药物诱导耐受的基础；
Nature. 1978 Jan 19;271(5642):255-7. doi: 10.1038/271255a0.
6
The value of an assessment of erythema and increase in thickness of the skin reaction for a full appreciation of the nature of delayed hypersensitivity in the guinea pig.对于充分理解豚鼠迟发型超敏反应的本质而言，评估红斑及皮肤反应厚度增加情况具有重要价值。
Int Arch Allergy Appl Immunol. 1977;54(1):58-66. doi: 10.1159/000231808.

豚鼠接触性敏感中抑制与效应机制之间关系的动力学

Kinetics of the relation between suppressor and effector mechanisms in contact sensitivity in the guinea-pig.

作者信息

Parker D, Turk J L

出版信息

Immunology. 1982 Sep;47(1):61-6.

PMID:6214499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555512/
Abstract

Cyclophosphamide (300 mg/kg) given before or up to 2 days after sensitization, induces increased contact skin reactions at 8 days. Reactions were suppressed with cyclophosphamide (CY) given between 3 and 5 days after sensitization; reactivity returned on day 10. CY, given on days 6 to 8, only suppressed reactions when skin tests were made 4 days later. This temporary depression of contact sensitivity corresponds with the maximal reduction of peripheral blood lymphocytes. CY given 1-2 days after DNFB produced decreased T-cell proliferation in local lymph nodes 4 days after sensitization. CY given 3 days after DNFB produced maximal T-cell suppression on 5 day nodes. Massive increase in T-cell proliferation in 5 day nodes occurred when CY was given on the day of sensitization or the day before. Thus CY given around sensitization acts mainly on suppressor cells whereas given later, the action is principally on the effector functions.

摘要

致敏前或致敏后2天内给予环磷酰胺（300mg/kg），可使8天时的接触性皮肤反应增强。致敏后3至5天给予环磷酰胺（CY）可抑制反应；10天时反应性恢复。致敏后6至8天给予CY，仅在4天后进行皮肤试验时抑制反应。这种接触敏感性的暂时降低与外周血淋巴细胞的最大减少相对应。DNFB后1 - 2天给予CY可使致敏后4天局部淋巴结中的T细胞增殖减少。DNFB后3天给予CY可使5天的淋巴结中T细胞受到最大抑制。致敏当天或前一天给予CY时，5天的淋巴结中T细胞增殖大量增加。因此，致敏前后给予CY主要作用于抑制细胞，而稍后给予则主要作用于效应功能。