环磷酰胺的作用及抑制细胞在迟发型超敏反应脱敏中的作用。
The effect of cyclophosphamide and role suppressor cells in the desensitization of delayed hypersensitivity.
作者信息
Parker D, Dwyer J M, Turk J L
出版信息
Immunology. 1981 May;43(1):191-6.
Desensitization of guinea-pigs with ovalbumin (OA) or bovine gamma globulin (BGG) induces strong specific desensitization and is associated with a non-specific energy to tuberculin--PPD. Similarly, it was found that animals receiving desensitizing injections of PPD have suppressed delayed hypersensitivity reactions to OA or BGG. PPD also induced strong specific desensitization. Cyclophosphamide (CY) given in one large dose (300 mg/kg) 3 days before immunization failed to affect the specific desensitization induced by all three antigens. However, if CY was given 1 day after immunization, it was not possible to induce specific desensitization. The induction of non-specific desensitization was prevented in all three antigen systems if CY was given either 3 days before or 1 day after immunization. Desensitization with either OA or BGG markedly suppressed the specific 4 hr Arthus reactions.
用卵清蛋白（OA）或牛γ球蛋白（BGG）对豚鼠进行脱敏可诱导强烈的特异性脱敏，并与对结核菌素——PPD的非特异性反应相关。同样，发现接受PPD脱敏注射的动物对OA或BGG的迟发型超敏反应受到抑制。PPD也诱导了强烈的特异性脱敏。在免疫前3天给予一次大剂量（300mg/kg）的环磷酰胺（CY）未能影响由所有三种抗原诱导的特异性脱敏。然而，如果在免疫后1天给予CY，则无法诱导特异性脱敏。如果在免疫前3天或免疫后1天给予CY，则在所有三种抗原系统中均阻止了非特异性脱敏的诱导。用OA或BGG进行脱敏可显著抑制特异性4小时阿瑟斯反应。
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