Kresina T F, Nisonoff A
J Exp Med. 1983 Jan 1;157(1):15-23. doi: 10.1084/jem.157.1.15.
Mice that are suppressed with respect to an idiotype (CRIA) present in A/J anti-p-azophenylarsonate antibodies, hyperimmunized, and allowed to rest were previously found to possess high concentrations of suppressor T cells with anti-idiotypic receptors. We have now observed that the sera of such mice contain soluble factors that can selectively suppress the CRIA component of a humoral response when passively transferred to adult or neonatal recipients. When T cells from suppressed, hyperimmunized mice were transferred into female mice before mating, their offspring, upon immunization, produced anti-Ar antibodies that lacked CRIA. A state of idiotypic suppression was also produced in offspring when the mother was inoculated with serum from suppressed mice a few days before parturition. The results indicate that the suppressor factor is not an immunoglobulin.
之前发现,对A/J抗对氨基苯胂酸抗体中存在的独特型(CRIA)有抑制作用的小鼠,经过超免疫并让其休息后,体内含有高浓度的带有抗独特型受体的抑制性T细胞。我们现在观察到,此类小鼠的血清含有可溶性因子,当将其被动转移给成年或新生受体时,可选择性抑制体液反应的CRIA成分。当将来自受抑制、超免疫小鼠的T细胞在交配前转移到雌性小鼠体内时,其后代在免疫后产生的抗Ar抗体缺乏CRIA。当母亲在分娩前几天接种受抑制小鼠的血清时,后代也会产生独特型抑制状态。结果表明,抑制因子不是一种免疫球蛋白。