鉴定三级抑制细胞激活所需的I-J+抗原呈递细胞。
Identification of an I-J+ antigen-presenting cell required for third order suppressor cell activation.
作者信息
Lowy A, Tominaga A, Drebin J A, Takaoki M, Benacerraf B, Greene M I
出版信息
J Exp Med. 1983 Jan 1;157(1):353-8. doi: 10.1084/jem.157.1.353.
Abstract
We have found that an I-J+ I-A- antigen-presenting cell (APC) is required for Ts3 activation in vivo. Together with the I-J restriction previously reported for Ts3 induction (Takaoki, M., M.-S. Sy, A. Tominaga, A. Lowy, M. Tsurifiji, B. Benacerraf, R. Finberg, and M. I. Greene, 1982, J. Exp. Med., 156:1325), it appears that this I-J+ APC is responsible for I-J restriction in the triggering of Ts3. This restriction may be exerted via a pre-Ts3 associative recognition of antigen and I-J encoded determinants, analogous to the T helper recognition of antigen in the context of I-A and I-E determinants.
摘要
我们发现，体内Ts3激活需要I-J⁺I-A⁻抗原呈递细胞（APC）。结合先前报道的Ts3诱导的I-J限制（高木，M.，M.-S. 西，A. 富永，A. 洛伊，M. 鹤桥，B. 贝纳塞拉夫，R. 芬伯格，和M. I. 格林，1982年，《实验医学杂志》，156:1325），看来这种I-J⁺APC在Ts3触发中负责I-J限制。这种限制可能通过Ts3前体对抗原和I-J编码决定簇的联合识别来施加，类似于T辅助细胞在I-A和I-E决定簇背景下对抗原的识别。
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