脱氧鸟苷酸和脱氧胞苷酸抗体与双链DNA的碱基特异性结合。
Base specific binding of deoxyguanylate and deoxycytidylate antibodies to double stranded DNA.
作者信息
Jacob A, Jacob T M
出版信息
Nucleic Acids Res. 1982 Oct 25;10(20):6273-80. doi: 10.1093/nar/10.20.6273.
Abstract
Antibodies raised in rabbits against deoxyguanylate and deoxycytidylate bind to 3H-lambda double stranded DNA and the binding is base specific. The concentrations of antibody populations that bind to double stranded DNA are much less than those binding to denatured DNA. Due to their low concentrations, these antibodies were not detected in earlier studies. These antibodies are expected to be useful to probe the conformational flexibilities of double stranded DNAs.
摘要
在兔子体内产生的针对脱氧鸟苷酸和脱氧胞苷酸的抗体可与³H-λ双链DNA结合，且这种结合具有碱基特异性。与双链DNA结合的抗体群体浓度远低于与变性DNA结合的抗体群体浓度。由于其浓度较低，这些抗体在早期研究中未被检测到。预计这些抗体将有助于探测双链DNA的构象灵活性。
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本文引用的文献
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