阿洛西林和美洛西林对正常兔及实验性铜绿假单胞菌脑膜炎兔脑脊液的穿透性比较。
Comparative penetration of azlocillin and mezlocillin into cerebrospinal fluid of normal rabbits and rabbits with experimentally induced Pseudomonas aeruginosa meningitis.
作者信息
Hodges G R, Worley S E
出版信息
Antimicrob Agents Chemother. 1982 Nov;22(5):909-11. doi: 10.1128/AAC.22.5.909.
Abstract
The impacts of meningeal infection with Pseudomonas aeruginosa and route of drug administration on the penetration of azlocillin and mezlocillin into the cerebrospinal fluid of rabbits were evaluated. The penetration of both agents was increased to a similar degree in rabbits with meningitis compared with normal rabbits. The increase in penetration was greater after intravenous administration than after intramuscular administration.
摘要
评估了铜绿假单胞菌脑膜感染及给药途径对阿洛西林和美洛西林在兔脑脊液中渗透的影响。与正常兔相比，脑膜炎兔中这两种药物的渗透率均有相似程度的增加。静脉给药后渗透率的增加大于肌肉注射后。
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