Nakayama H, Nakayama K, Nakayama R, Kato Y
Arch Microbiol. 1982 Oct;132(4):308-12. doi: 10.1007/BF00413380.
Pantolactone and butyrolactone, known to suppress cell filament formation in the lon mutant of Escherichia coli, were found also to be capable of partially correcting other anomalies of the mutant including impaired lysogenization with bacteriophages lambda and Pl and increased synthesis of colanic acid. In contrast to pantolactone, which inhibited thermal induction of cell filament formation and lambda prophage in the tif mutant as previously described, butyrolactone enhanced these phenomena. It was inferred that whereas these substances exert their effects through acting upon the tif-recA protein in the tif bacterium, there is a distinct target for their characteristic actions in the lon mutant.
已知泛内酯和丁内酯可抑制大肠杆菌lon突变体中的细胞丝形成，还发现它们能够部分纠正该突变体的其他异常情况，包括噬菌体λ和P1的溶原化受损以及结肠酸合成增加。与之前描述的抑制tif突变体细胞丝形成和λ原噬菌体热诱导的泛内酯不同，丁内酯增强了这些现象。据推测，尽管这些物质通过作用于tif细菌中的tif-recA蛋白发挥作用，但在lon突变体中存在其特征性作用的独特靶点。
