由针对异种肾部分3抗原的异种抗体在大鼠中产生的被动海曼肾炎。
Passive Heymann nephritis in the rat produced by a heterologous antibody to a heterologous kidney fraction 3 antigen.
作者信息
Barabas A Z, Cornish J, Lannigan R
出版信息
Br J Exp Pathol. 1982 Dec;63(6):667-70.
Abstract
Antibody to rabbit kidney Fraction 3 antigen was raised in guinea-pigs. In an indirect fluorescent antibody test the guinea-pig sera showed high levels of antibody to both rabbit and rat tubular nephritogenic antigen and a much lower level of antibody against their own kidney tubular antigen. I.v. injection of this guinea-pig anti-rabbit kidney Fraction 3 antibody into rats produced immune-complex glomerulonephritis, morphologically identical to passive Heymann nephritis.
摘要
针对兔肾第3组分抗原的抗体在豚鼠体内产生。在间接荧光抗体试验中，豚鼠血清显示出针对兔和大鼠肾小管致肾炎抗原的高水平抗体，而针对其自身肾小管抗原的抗体水平则低得多。将这种豚鼠抗兔肾第3组分抗体静脉注射到大鼠体内可产生免疫复合物性肾小球肾炎，其形态与被动海曼肾炎相同。
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