用一种通用的高压液相色谱法测定血清和肌肉组织中的头孢哌酮浓度。
Determination of cefoperazone concentration in serum and muscle tissue with a versatile high-pressure liquid chromatographic method.
作者信息
Muder R R, Diven W F, Yu V L, Johnson J
出版信息
Antimicrob Agents Chemother. 1982 Dec;22(6):1076-8. doi: 10.1128/AAC.22.6.1076.
Abstract
A rapid, specific, and reproducible high-pressure liquid chromatographic method was developed for the determination of cefoperazone concentration in serum and tissue. The assay uses a simple methanol extraction, with cefoxitin as the internal standard. The limits of detection are 1 to 150 micrograms/ml; the maximum coefficient of variation is 7.4%. Using the same chromatography column, muBondapak phenyl, and mobile-phase 0.005 M tetrabutylammonium buffer-acetonitrile (80:20), the method can be easily adapted for the analysis of cefoxitin and moxalactam.
摘要
已开发出一种快速、特异且可重复的高压液相色谱法，用于测定血清和组织中的头孢哌酮浓度。该测定采用简单的甲醇萃取法，以头孢西丁作为内标。检测限为1至150微克/毫升；最大变异系数为7.4%。使用相同的色谱柱（μBondapak苯基柱）和流动相（0.005M四丁基铵缓冲液-乙腈，80:20），该方法可轻松适用于头孢西丁和莫西沙星的分析。
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