Reimer R R, Clark W H, Greene M H, Ainsworth A M, Fraumeni J F
JAMA. 1978 Feb 20;239(8):744-6.
In seven consecutive melanoma-prone families, pigmented lesions with distinctive clinical and histologic characteristics occurred in 18 of 20 melanoma patients (90%) and 24 of 43 first-degree relatives (56%). Recognition of these lesions led to the detection of early-stage melanoma in six family members. This syndrome appears to represent an autosomal dominant trait and may serve as a cutaneous marker to identify persons at high risk for melanoma.
在连续的7个易患黑色素瘤的家族中，20名黑色素瘤患者中有18名（90%）以及43名一级亲属中有24名（56%）出现了具有独特临床和组织学特征的色素沉着病变。对这些病变的识别使得6名家庭成员的早期黑色素瘤得以被发现。这种综合征似乎代表一种常染色体显性性状，并且可能作为一种皮肤标志物来识别黑色素瘤高危人群。
