Greene M H, Reimer R R, Clark W H, Mastrangelo M J
Semin Oncol. 1978 Mar;5(1):85-7.
Familial occurrences of malignant melanoma may be related to an inherited syndrome of precursor cutaneous lesions with distinct clinical and histologic features. Recognition of the syndrome in the relatives of melanoma patients identifies a subset of family members at high risk for melanoma, facilitating their early diagnosis and treatment. Further studies of these families may provide insight into the biology of malignant melanoma and the pathophysiology of malignant transformation in benign nevi.
恶性黑色素瘤的家族性发病可能与一种具有独特临床和组织学特征的皮肤前驱病变遗传综合征有关。在黑色素瘤患者的亲属中识别出该综合征，可确定一部分患黑色素瘤风险较高的家庭成员，便于他们的早期诊断和治疗。对这些家族的进一步研究可能会为恶性黑色素瘤的生物学特性以及良性痣恶变的病理生理学提供深入了解。
