Rubinstein A, Sicklick M, Mehra V, Rosen F S, Levey R H
J Clin Invest. 1981 Jan;67(1):42-50. doi: 10.1172/JCI110031.
A patient with acquired agammaglobulinemia had an antihelper T cell factor that was identified as an immunoglobulin of the IgG class. The factor specifically bound to the TH2- T cell subset and, in the presence of complement, abolished the helper effect of normal T cells. The antihelper T cell antibody preceded by several years the appearance of suppressor TH2+Ia+ T cells, at which time the clinical course rapidly deteriorated. Plasmapheresis resulted in lymphocytosis and reappearance of a functionally intact helper T cell population. It did not affect the suppressor cells. Conversely, total thymectomy resulted in a temporary disappearance of the TH2+Ia+ suppressor cells, but did not decrease the levels of the autoantibody to helper T cells. Neither of these treatments reversed the state of agammaglobulinemia.
一名获得性无丙种球蛋白血症患者有一种抗辅助性T细胞因子，该因子被鉴定为IgG类免疫球蛋白。该因子特异性结合TH2-T细胞亚群，并且在补体存在的情况下，消除了正常T细胞的辅助作用。抗辅助性T细胞抗体在抑制性TH2+Ia+T细胞出现前数年就已存在，此时临床病程迅速恶化。血浆置换导致淋巴细胞增多以及功能完整的辅助性T细胞群体重新出现。它对抑制性细胞没有影响。相反，全胸腺切除术导致TH2+Ia+抑制性细胞暂时消失，但并未降低抗辅助性T细胞自身抗体的水平。这两种治疗方法均未逆转无丙种球蛋白血症的状态。
