Dick S J, Macchi B, Papazoglou S, Oldfield E H, Kornblith P L, Smith B H, Gately M K
Science. 1983 May 13;220(4598):739-42. doi: 10.1126/science.6220469.
Certain human glioma lines produce mucopolysaccharide coats that impair the generation of cytolytic lymphocytes in response to these lines in vitro. Coat production is substantially enhanced by the interaction of glioma cells with a macromolecular factor released by human peripheral blood mononuclear cells in culture. This interaction thus constitutes an unusual mechanism by which inflammatory cells may nonspecifically suppress the cellular immune response to at least one class of solid tumors in humans.
某些人类胶质瘤细胞系会产生黏多糖包膜，这会损害体外针对这些细胞系产生溶细胞性淋巴细胞的能力。胶质瘤细胞与培养的人外周血单核细胞释放的一种大分子因子相互作用，会显著增强包膜的产生。因此，这种相互作用构成了一种不同寻常的机制，通过该机制炎症细胞可能会非特异性地抑制人类对至少一类实体瘤的细胞免疫反应。
