X连锁无丙种球蛋白血症患者中与迟发性皮肤过敏反应受损相关的CD4淋巴细胞亚群异常。
CD4 lymphocyte subset abnormalities associated with impaired delayed cutaneous hypersensitivity reactions in patients with X-linked agammaglobulinaemia.
作者信息
Crockard A D, Boyd N A, McNeill T A, McCluskey D R
机构信息
Regional Immunology Laboratory, Royal Victoria Hospital, Queen's University of Belfast, Northern Ireland.
出版信息
Clin Exp Immunol. 1992 Apr;88(1):29-34. doi: 10.1111/j.1365-2249.1992.tb03034.x.
Abstract
Circulating CD4 lymphocyte subset (CD45RA; CD45RO; CD29; Leu8) levels were determined in nine patients with X-linked agammaglobulinaemia (XLA), nine patients with common variable immunodeficiency (CVI) and in 18 age- and sex-matched controls. CD4CD45RO and CD4CD29 cells were significantly lower (P less than 0.01) in the XLA patient group (CD45RO, 15.7 +/- 10.2%; CD4CD29, 32.1 +/- 14.6%) compared with CVI patients (61.8 +/- 25.4%; 60.1 +/- 11.2%) and normal controls (43.7 +/- 22.3%, 54.5 +/- 22.0%). The levels of CD4CD45RA and CD4Leu8 cells were not abnormal in the XLA patient group. No selective reduction in CD4 subsets was observed in the CVI patient group. Delayed cutaneous hypersensitivity testing of five XLA and five CVI patients revealed a significantly reduced response to recall antigens in patients with XLA. This may relate to the deficiency of circulating memory T cells observed in these patients.
摘要
测定了9例X连锁无丙种球蛋白血症（XLA）患者、9例常见变异型免疫缺陷（CVI）患者以及18名年龄和性别匹配的对照者的循环CD4淋巴细胞亚群（CD45RA、CD45RO、CD29、Leu8）水平。与CVI患者（61.8±25.4%；60.1±11.2%）和正常对照者（43.7±22.3%，54.5±22.0%）相比，XLA患者组的CD4CD45RO和CD4CD29细胞显著降低（P<0.01）（CD45RO，15.7±10.2%；CD4CD29，32.1±14.6%）。XLA患者组的CD4CD45RA和CD4Leu8细胞水平无异常。CVI患者组未观察到CD4亚群的选择性降低。对5例XLA患者和5例CVI患者进行的迟发性皮肤超敏反应试验显示，XLA患者对回忆抗原的反应显著降低。这可能与这些患者中观察到的循环记忆T细胞缺乏有关。
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