Seski J C, Reinhalter E R, Silva J
Obstet Gynecol. 1978 Feb;51(2):188-92.
The cellular immunity of 16 women with recalcitrant condylomata acuminata was investigated with an in vitro assay of antigen-induced lymphocyte transformations. Results were compared to those of 24 age-matched controls. Lymphocyte transformation responses (in counts per minute) for women with condylomata were much lower than controls for phytohemagglutinin-P, 32,285 and 60,015, (P less than .001); for concanavallin A, 28,664 and 58,605, (P less than .001); and for pokeweed mitogen, 34,941 and 73,394 (P less than .0001). No significant differences in lymphocyte transformations were noted between the 2 groups to Candida or streptokinase-streptodornase antigens. Immunosuppressive diseases, recurrent infections, and intraepithelial neoplasms of the genital tract were more frequent in the group of women with condylomata, and this seems to clinically substantiate the depressions noted in their in vitro cellular immunity. A refractory course of condyloma acuminatum in some women may be a reflection of an underlying state of immunosuppression.
采用抗原诱导淋巴细胞转化的体外试验，对16例顽固性尖锐湿疣女性患者的细胞免疫进行了研究。将结果与24例年龄匹配的对照者进行比较。尖锐湿疣女性患者对植物血凝素-P的淋巴细胞转化反应（每分钟计数）显著低于对照组，分别为32,285和60,015（P<0.001）；对刀豆蛋白A的反应分别为28,664和58,605（P<0.001）；对商陆有丝分裂原的反应分别为34,941和73,394（P<0.0001）。两组对念珠菌或链激酶-链道酶抗原的淋巴细胞转化无显著差异。尖锐湿疣女性患者中免疫抑制性疾病、反复感染和生殖道上皮内瘤变更为常见，这在临床上似乎证实了其体外细胞免疫的低下。部分女性尖锐湿疣病程难治可能反映了潜在的免疫抑制状态。
