Ryley J F, Hardman L
Parasitology. 1978 Feb;76(1):11-20. doi: 10.1017/s003118200004734x.
Vitamin K (as menaphthone sodium bisulphite) added to a deficient diet reduced mortality due to Eimeria tenella or E. necatrix, had a slight effect on haematocrit, but had no obvious effect on weight gain or faecal blood; 0.1 ppm gave a maximal response. The effect of vitamin K on mortality was not absolute; the magnitude of the effect depended on the size of the challenge dose of oocysts. Likewise, the response of an infection to anticoccidial drugs, particularly monensin, depended on the severity of challenge. The effect of adding vitamin K in the presence of drug was to effectively reduce the coccidial challenge; no other interaction of vitamin K and drug has been found. No effects with vitamin K deficiency or supplementation were seen in cases of infections with E. acervulina, E. brunetti or E. maxima. The use of a deficient diet for experimental work is therefore quite justified--particularly as it results in a 4-fold saving of oocysts for inoculation purposes in the case of the haemorrhagic species.
向缺乏维生素K的日粮中添加维生素K（亚硫酸氢钠甲萘醌）可降低由柔嫩艾美耳球虫或毒害艾美耳球虫引起的死亡率，对血细胞比容有轻微影响，但对体重增加或粪便带血无明显影响；0.1 ppm时效果最佳。维生素K对死亡率的影响并非绝对；其影响程度取决于卵囊攻击剂量的大小。同样，感染对抗球虫药（尤其是莫能菌素）的反应也取决于攻击的严重程度。在有药物存在的情况下添加维生素K的作用是有效降低球虫攻击；未发现维生素K与药物有其他相互作用。在感染堆型艾美耳球虫、布氏艾美耳球虫或巨型艾美耳球虫的情况下，未观察到维生素K缺乏或补充的影响。因此，在实验工作中使用缺乏维生素K的日粮是完全合理的——特别是因为在出血性球虫种类的情况下，这样做可使接种用的卵囊节省四倍。
