van Heerde P, Feltkamp C A, Feltkamp-Vroom T M, Koudstaal J
Acta Cytol. 1983 May-Jun;27(3):306-12.
The cytologic features of a highly malignant sarcomatous tumor in a 37-year-old male, arising from interdigitating cells and localized in the mediastinum, lymph nodes and skin, are described. Cytologically this sarcoma was characterized by large cells with ill-defined, faintly basophilic cytoplasm, monocytoid or multilobulated nuclei and a reticular chromatin structure; very prominent nucleoli were seen in some of the cells. Some of the tumor cells were spindle shaped. The ultrastructurally characteristic invaginations of the cell membrane were not obvious in the cytologic smear, although the nuclear membrane showed deep, narrow, channel-like indentations. The specific ultrastructural, immunologic and cytochemical characteristics of the interdigitating cells were recognized in the tumor cells. Adenosine triphosphatase was present in the tumor cells in large amounts, while acid phosphatase, acid alpha-naphthyl acetate esterase and other enzymes were absent. The described tumor must be considered another tumor of the mononuclear phagocyte system; the proposed name is "interdigitating-cell sarcoma."
本文描述了一名37岁男性的高度恶性肉瘤样肿瘤的细胞学特征，该肿瘤起源于指状突细胞，位于纵隔、淋巴结和皮肤。细胞学上，这种肉瘤的特征是细胞大，胞质不清晰、淡嗜碱性，单核或多叶核，染色质呈网状结构；部分细胞可见非常明显的核仁。部分肿瘤细胞呈梭形。尽管核膜显示出深的、狭窄的、通道样凹陷，但细胞膜的超微结构特征性内陷在细胞学涂片中并不明显。肿瘤细胞中可识别出指状突细胞的特定超微结构、免疫和细胞化学特征。肿瘤细胞中大量存在三磷酸腺苷酶，而酸性磷酸酶、酸性α-萘乙酸酯酶和其他酶则不存在。所述肿瘤必须被视为单核吞噬细胞系统的另一种肿瘤；建议命名为“指状突细胞肉瘤”。
