大鼠佐剂性关节炎中低剂量诱导抑制细胞的特性研究
Characterization of low dose induced suppressor cells in adjuvant arthritis in rats.
作者信息
Tsukano M, Nawa Y, Kotani M
出版信息
Clin Exp Immunol. 1983 Jul;53(1):60-6.
Characterization of suppressor cells in adjuvant arthritis was performed by using highly susceptible DA strain rats. The results showed that suppressor cells were induced after a single inoculation of subarthritogenic dose of mycobacterial adjuvant. Relatively long incubation period was required for the induction of suppressor cells. Such cells were predominated in the draining lymph node and, after fractionation, only sIg- population was effective in conferring unresponsiveness. In vivo irradiation or hydrocortisone treatment suggested that low dose induced suppressor cells were resistant against such immunosuppressive treatments. In addition, by using alkyldiamine as a non-mycobacterial arthritogenic adjuvant, it was suggested that unresponsiveness induced by low dose priming with mycobacterial adjuvant was antigen specific.
通过使用高度易感的DA品系大鼠对佐剂性关节炎中的抑制细胞进行了表征。结果表明，在单次接种亚致关节炎剂量的分枝杆菌佐剂后诱导出了抑制细胞。诱导抑制细胞需要相对较长的潜伏期。此类细胞在引流淋巴结中占主导地位，分级分离后，只有表面免疫球蛋白阴性（sIg-）群体在赋予无反应性方面有效。体内照射或氢化可的松治疗表明，低剂量诱导的抑制细胞对这种免疫抑制治疗具有抗性。此外，通过使用烷基二胺作为非分枝杆菌致关节炎佐剂，提示低剂量分枝杆菌佐剂引发所诱导的无反应性是抗原特异性的。
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