Tsukano M, Kotani M, Matsuno K, Miyakawa K, Nawa Y
Experientia. 1985 Oct 15;41(10):1337-8. doi: 10.1007/BF01952083.
The induction of unresponsiveness to mycobacterial adjuvant took a longer time in male DA rats than in female rats. A shift in the induction time of unresponsiveness in males toward the female type was brought about by castration, but could be reverted to the male type by the application of testosterone. The transfer study revealed that cells capable of preventing arthritis required a longer incubation time for their development in males than in females. This suggests that testosterone inhibits the development of suppressor cells in adjuvant arthritis.
雄性DA大鼠对分枝杆菌佐剂无反应性的诱导时间比雌性大鼠长。阉割使雄性大鼠无反应性诱导时间向雌性类型转变，但通过应用睾酮可恢复为雄性类型。转移研究表明，在佐剂性关节炎中，能够预防关节炎的细胞在雄性大鼠中发育所需的孵育时间比雌性大鼠长。这表明睾酮抑制了佐剂性关节炎中抑制性细胞的发育。
