Meerson F Z, Sukhomlinov A B, Evsev'eva M E, Abdikaliev N A
Kardiologiia. 1983 Jun;23(6):94-9.
Structural and functional disorders of the heart muscle were studied in rats with phenylhydrazine-induced chronic hemolytic anemia, as was the possibility of their prevention with anti-oxidant Ionol, a lipid peroxidation inhibitor. Hemolytic anemia was shown to produce myocardial contractural damage, myocytolysis, fatty infiltration, small-focal necrosis, the so-called central lumpy decay phenomenon. These lesions are accompanied with depressed cardiac contractility. Although anti-oxidant Ionol, a lipid peroxidation inhibitor, administered to animals simultaneously with phenylhydrazine, does not prevent hemolytic anemia, it reduces twofold the number of lesion foci in the heart muscle and limits significantly the depression of cardiac contractility.
在苯肼诱导的慢性溶血性贫血大鼠中研究了心肌的结构和功能紊乱，以及用抗氧化剂益康唑（一种脂质过氧化抑制剂）预防这些紊乱的可能性。结果表明，溶血性贫血会导致心肌收缩性损伤、肌细胞溶解、脂肪浸润、小灶性坏死，即所谓的中央块状坏死现象。这些病变伴有心脏收缩力下降。尽管在给动物注射苯肼的同时给予抗氧化剂益康唑（一种脂质过氧化抑制剂）并不能预防溶血性贫血，但它能使心肌损伤灶的数量减少一半，并显著减轻心脏收缩力的下降。
