Antonenkov V D, Tsyplenkova V G, Vikhert A M
Biull Eksp Biol Med. 1990 May;109(5):446-9.
Ultrastructure and peroxide metabolism of rat myocardium were studied after alcohol administration and partial inhibition of catalase with amino-triazole. There were obtained morphological pattern of alcoholic cardiomyopathy and activation of lipid peroxidation in myocardium under these experimental conditions. Cardiomyocyte ultrastructure and level of lipid peroxidation were improved after treatment with antioxidant-dibunol in high doses (40 and 100 mg/kg). These data indicate the main role of lipid peroxidation in the pathogenesis of alcoholic cardiomyopathy and possibility of its therapy with antioxidants.
在给予酒精并使用氨基三唑部分抑制过氧化氢酶后，对大鼠心肌的超微结构和过氧化物代谢进行了研究。在这些实验条件下，获得了酒精性心肌病的形态学模式以及心肌中脂质过氧化的激活。高剂量（40和100mg/kg）抗氧化剂二丁基羟基甲苯治疗后，心肌细胞超微结构和脂质过氧化水平得到改善。这些数据表明脂质过氧化在酒精性心肌病发病机制中的主要作用以及用抗氧化剂治疗该病的可能性。
