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镰刀菌和漆斑菌霉菌毒素对酿酒酵母脱氢酶活性的影响。

Influence of Fusarium and Myrothecium mycotoxins on dehydrogenase activity of Saccharomyces cerevisiae.

作者信息

Reiss J

出版信息

Mycopathologia. 1983 Mar 22;81(3):187-9. doi: 10.1007/BF00436826.

DOI:10.1007/BF00436826
PMID:6225024
Abstract

The Fusarium and Myrothecium mycotoxins roridin A, diacetoxyscirpenol, verrucarin A, T-2 toxin and zearalenone (10(-2) and 10(-3) mg/ml) inhibit the unspecific dehydrogenase activity of baker's yeast (Saccharomyces cerevisiae) in vivo. The action of these toxins is in the same order as that of aflatoxin B1. It is suggested that at least the trichothecenes decrease the dehydrogenase activity by an interaction with thiol groups of the active center of the enzymes.

摘要

镰刀菌和炭角菌的霉菌毒素，如萝里丁A、二醋酸藨草镰刀菌烯醇、疣孢菌素A、T-2毒素和玉米赤霉烯酮（10^(-2)和10^(-3)毫克/毫升）在体内可抑制面包酵母（酿酒酵母）的非特异性脱氢酶活性。这些毒素的作用顺序与黄曲霉毒素B1相同。有人提出，至少单端孢霉烯族毒素是通过与酶活性中心的巯基相互作用来降低脱氢酶活性的。

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Influence of Fusarium and Myrothecium mycotoxins on dehydrogenase activity of Saccharomyces cerevisiae.镰刀菌和漆斑菌霉菌毒素对酿酒酵母脱氢酶活性的影响。
Mycopathologia. 1983 Mar 22;81(3):187-9. doi: 10.1007/BF00436826.
2
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3
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本文引用的文献

1
[Mycotoxins in foods. IV. Effect of byssochlamic acid, aflatoxin B1 and luteoskyrin on some enzymes].[食品中的霉菌毒素。IV. 柄曲霉素、黄曲霉毒素B1和黄绿青霉素对某些酶的影响]
Zentralbl Bakteriol Parasitenkd Infektionskr Hyg. 1970;125(5):520-4.
2
Structure-function relationship in the 12,13-epoxytrichothecenes. Novel inhibitors of protein synthesis.12,13-环氧单端孢霉烯族毒素的结构-功能关系。新型蛋白质合成抑制剂。
Biochem Biophys Res Commun. 1974 Apr 8;57(3):838-44. doi: 10.1016/0006-291x(74)90622-6.
3
Influence of the mycotoxins aflatoxin B1, rubratoxin B, patulin and diacetoxyscirpenol on the fermentation activity of baker's yeast.
对T-2毒素具有抗性的酿酒酵母突变体的分离与鉴定
Curr Genet. 1988 May;13(5):363-8. doi: 10.1007/BF00365656.
霉菌毒素黄曲霉毒素B1、红天精、展青霉素和二醋酸藨草镰刀菌烯醇对面包酵母发酵活性的影响。
Mycopathol Mycol Appl. 1973 Dec 15;51(4):337-45. doi: 10.1007/BF02057804.
4
Comparative toxicology of trichothec mycotoxins: inhibition of protein synthesis in animal cells.单端孢霉烯族霉菌毒素的比较毒理学：对动物细胞蛋白质合成的抑制作用
J Biochem. 1973 Aug;74(2):285-96.
5
Enhancement of the activity of beef muscle lactate dehydrogenase by aflatoxin B1 in vitro.体外黄曲霉毒素B1对牛肉肌肉乳酸脱氢酶活性的增强作用。
Taiwan Yi Xue Hui Za Zhi. 1974 Jan;73(1):16-21.
6
Inactivation of some thiol-enzymes by trichothecene mycotoxins from Fusarium species.镰刀菌属的单端孢霉烯族霉菌毒素对某些硫醇酶的失活作用。
Chem Pharm Bull (Tokyo). 1975 Oct;23(10):2439-42. doi: 10.1248/cpb.23.2439.
7
Ochratoxin A-induced mycotoxic porcine nephropathy: alterations in enzyme activity in tubular cells.赭曲霉毒素A诱导的猪霉菌毒素性肾病：肾小管细胞酶活性的改变
Acta Pathol Microbiol Scand A. 1979 Jul;87A(4):237-43. doi: 10.1111/j.1699-0463.1979.tb00048.x.
8
Action of aflatoxin on some redox enzymes and complexes of avian liver mitochondria.
Biochem Med. 1979 Aug;22(1):27-32. doi: 10.1016/0006-2944(79)90033-4.
9
Effect of aflatoxin B1 on pyridine nucleotides and NADP linked dehydrogenases.黄曲霉毒素B1对吡啶核苷酸和NADP连接的脱氢酶的影响。
Br J Exp Pathol. 1975 Oct;56(5):423-8.