镰刀菌毒素的免疫抑制活性。粗提物、T2毒素和二醋酸雪腐镰刀菌烯醇对抗体合成及皮肤移植的影响。
Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis and skin grafts of crude extracts, T2-toxin and diacetoxyscirpenol.
作者信息
Rosenstein Y, Lafarge-Frayssinet C, Lespinats G, Loisillier F, Lafont P, Frayssinet C
出版信息
Immunology. 1979 Jan;36(1):111-7.
Abstract
The inhibitory effect of crude Fusarium poae extracts, T2-toxin and diacetoxyscirpenol on synthesis of antibody to sheep red blood cells was investigated, as well as the effect of T2-toxin on skin graft rejection. Fusarium crude extracts, T2-toxin and diacetoxyscirpenol cause a significant reduction in thymus weight and inhibit responsiveness to sheep red blood cells. The effect on antibody synthesis was critically dependent on the drug doses used. The effect of an immunosuppressive dose of T2-toxin disappeared within 6 days after the end of the treatment. The administration of T2-toxin subsequent to immunization stops antibody synthesis. T2-toxin significantly prolongs the period required for skin graft rejection.
摘要
研究了禾谷镰刀菌粗提物、T-2毒素和二醋酸藨草镰刀菌烯醇对绵羊红细胞抗体合成的抑制作用，以及T-2毒素对皮肤移植排斥反应的影响。禾谷镰刀菌粗提物、T-2毒素和二醋酸藨草镰刀菌烯醇可导致胸腺重量显著减轻，并抑制对绵羊红细胞的反应性。对抗体合成的影响严重依赖于所用药物的剂量。免疫抑制剂量的T-2毒素的作用在治疗结束后6天内消失。免疫后给予T-2毒素可阻止抗体合成。T-2毒素显著延长了皮肤移植排斥所需的时间。
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