Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis and skin grafts of crude extracts, T2-toxin and diacetoxyscirpenol.
作者信息
Rosenstein Y, Lafarge-Frayssinet C, Lespinats G, Loisillier F, Lafont P, Frayssinet C
出版信息
Immunology. 1979 Jan;36(1):111-7.
Abstract
The inhibitory effect of crude Fusarium poae extracts, T2-toxin and diacetoxyscirpenol on synthesis of antibody to sheep red blood cells was investigated, as well as the effect of T2-toxin on skin graft rejection. Fusarium crude extracts, T2-toxin and diacetoxyscirpenol cause a significant reduction in thymus weight and inhibit responsiveness to sheep red blood cells. The effect on antibody synthesis was critically dependent on the drug doses used. The effect of an immunosuppressive dose of T2-toxin disappeared within 6 days after the end of the treatment. The administration of T2-toxin subsequent to immunization stops antibody synthesis. T2-toxin significantly prolongs the period required for skin graft rejection.
摘要
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本文引用的文献
1
Toxicologic research on substances fro Fusarium nivale.
Cancer Res. 1968 Nov;28(11):2393-6.
2
Further improvements in the plaque technique for detecting single antibody-forming cells.
Immunology. 1968 Apr;14(4):599-600.
3
Toxicological approaches to the metabolites of Fusaria. 3. Acute toxicity of fusarenon-X.
Jpn J Exp Med. 1971 Dec;41(6):521-39.
4
Identification of T-2 toxin in moldy corn associated with a lethal toxicosis in dairy cattle.
Appl Microbiol. 1972 Nov;24(5):684-90. doi: 10.1128/am.24.5.684-690.1972.
5
6
Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins.
Proc Natl Acad Sci U S A. 1974 Jan;71(1):30-4. doi: 10.1073/pnas.71.1.30.
7
Reconfirmation of the specific nature of reticulocytes bioassay system to trichothec mycotoxins of Fusarium spp.
Chem Pharm Bull (Tokyo). 1974 Nov;22(11):2744-6. doi: 10.1248/cpb.22.2744.
8
Follicular lymphoma with deposits of amorphous hyaline material.
J Pathol. 1974 Jan;112(1):27-31. doi: 10.1002/path.1711120106.
9
Toxicological approaches to the toxic metabolites of Fusaria. VIII. Acute and subacute toxicities of T-2 toxin in cats.
Jpn J Pharmacol. 1975 Jun;25(3):263-70. doi: 10.1254/jjp.25.263.
10
Mechanism of action of the 12,13-epoxytrichothecene, anguidine, an inhibitor of protein synthesis.
Biochim Biophys Acta. 1976 Dec 1;454(2):273-84. doi: 10.1016/0005-2787(76)90230-6.
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