感染罗德西亚锥虫的无胸腺（nu/nu）小鼠中T细胞活性的诱导。
Induction of T cell activity in athymic (nu/nu) mice infected with Trypanosoma rhodesiense.
作者信息
Langhorne J, Rollwagen F M, Finerty J F
出版信息
Cell Immunol. 1983 Oct 1;81(1):180-6. doi: 10.1016/0008-8749(83)90224-1.
PMID:6225524
Abstract
Infection of C57BL/10 (B10)3 nu/nu mice with Trypanosoma rhodesiense results in the development of significant T-cell reactivity in spleen and lymph nodes. The proliferative responses to mitogens, such as concanavalin A (Con A) and phytohemagglutinin (PHA), and in mixed-lymphocyte reactions (MLR) to alloantigens are enhanced compared with control uninfected nu/nu mice. These results serve to emphasize the stimulatory nature of trypanosomes on the immune system.
摘要
用罗德西亚锥虫感染C57BL/10（B10）3裸鼠会导致脾脏和淋巴结中出现显著的T细胞反应性。与未感染的对照裸鼠相比，对丝裂原（如刀豆球蛋白A（Con A）和植物血凝素（PHA））的增殖反应以及对同种异体抗原的混合淋巴细胞反应（MLR）增强。这些结果强调了锥虫对免疫系统的刺激性质。
Zotero 插件