Gilbreath M J, Pavanand K, MacDermott R P, Wells R A, Ussery M A
Clin Exp Immunol. 1983 Feb;51(2):232-8.
Characterization of cold reactive lymphocytotoxic antibodies present in sera from Thai adults with malaria revealed that the antibodies are predominantly 19S (IgM), directed against both autologous and allogeneic mononuclear cells, complement-dependent, present in titres ranging from 1:2 to 1:16, and exhibit greater lymphocytotoxic activity during the acute stage of malarial infection than during the convalescent stage. The lymphocytotoxic antibodies were primarily directed against B cell targets or both B as well as T cell targets. In addition some sera were reactive with enriched monocyte/macrophage indicator cells at 15 degrees C, but not 37 degrees C. Antibodies directed against B cell targets were lymphocytotoxic both at 15 degrees C as well as 37 degrees C. The results indicate that IgM lymphocytotoxic antibodies in the sera of patients with malaria are directed primarily against B cells with reactivity to a lesser extent against T cells and macrophages and thus may play an immunoregulatory function in the humoral immune response to malaria infection.
对泰国成年疟疾患者血清中存在的冷反应性淋巴细胞毒性抗体的特性分析显示，这些抗体主要为19S（IgM），针对自体和异体单核细胞，依赖补体，效价范围为1:2至1:16，并且在疟疾感染急性期比恢复期表现出更强的淋巴细胞毒性活性。淋巴细胞毒性抗体主要针对B细胞靶标或同时针对B细胞和T细胞靶标。此外，一些血清在15℃时与富集的单核细胞/巨噬细胞指示细胞发生反应，但在37℃时不发生反应。针对B细胞靶标的抗体在15℃和37℃时均具有淋巴细胞毒性。结果表明，疟疾患者血清中的IgM淋巴细胞毒性抗体主要针对B细胞，对T细胞和巨噬细胞的反应性较低，因此可能在疟疾感染的体液免疫反应中发挥免疫调节功能。
