不同实验性自身免疫性疾病期间诱导产生的抑制细胞的部分交叉反应性。
Partial cross-reactivity by suppressor cells induced during different experimental autoimmune diseases.
作者信息
Playfair J H, De Souza J B, Hutchings P R, Cooke A
出版信息
Clin Exp Immunol. 1985 Jan;59(1):117-22.
Following injection of rat red cells, mice develop anti-red cell autoantibodies and subsequently suppressor T cells specific for these. Likewise, following recovery from non-lethal malaria, they develop suppressor T cells which suppress the anti-lymphocyte autoantibodies induced by lethal malaria parasites. Neither type of suppressor cell affected non-autoantibody components of the response, nor a response to sheep red cells. However, there was variable but significant cross-suppression of the respective autoantibody responses by both types of suppressor cell. Possible reasons for this unexpected cross-reaction are discussed.
注射大鼠红细胞后，小鼠会产生抗红细胞自身抗体，随后产生针对这些抗体的抑制性T细胞。同样，从非致死性疟疾中恢复后，它们会产生抑制性T细胞，这些细胞可抑制由致死性疟原虫诱导产生的抗淋巴细胞自身抗体。这两种类型的抑制性细胞均不影响反应中的非自身抗体成分，也不影响对绵羊红细胞的反应。然而，这两种类型的抑制性细胞对各自的自身抗体反应均有不同程度但显著的交叉抑制作用。文中讨论了这种意外交叉反应的可能原因。
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