chronological和生理年龄影响来自糖尿病、糖尿病前期和正常供体的成纤维细胞的复制寿命。 （注：原文中chronologic拼写有误，正确拼写为chronological ）
Chronologic and physiologic age affect replicative life-span of fibroblasts from diabetic, prediabetic, and normal donors.
作者信息
Goldstein S, Moerman E J, Soeldner J S, Gleason R E, Barnett D M
出版信息
Science. 1978 Feb 17;199(4330):781-2. doi: 10.1126/science.622567.
PMID:622567
Abstract
Cultured skin fibroblasts from subjects with clinically apparent diabetes mellitus and from subjects genetically predisposed to diabetes have a replicative lifespan that is inversely related to donor age. Fibroblasts from carefully defined normal subjects not predisposed to diabetes fail to show this correlation. The data support the idea that physiologic status of the tissue donor is a more precise determinant of fibroblast replicative lifespan than chronologic age.
摘要
来自临床诊断患有糖尿病的受试者以及有糖尿病遗传易感性受试者的培养皮肤成纤维细胞，其复制寿命与供体年龄呈负相关。来自精心界定的无糖尿病遗传易感性正常受试者的成纤维细胞则未显示出这种相关性。这些数据支持这样一种观点，即组织供体的生理状态比实际年龄更能精确地决定成纤维细胞的复制寿命。
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