Owens C J, Brackett N C
South Med J. 1978 Jan;71(1):43-6. doi: 10.1097/00007611-197801000-00013.
Twelve hypertensive patients had measurements of body weight, blood pressure, plasma renin activity, and plasma volume during periods of normal sodium intake and acute sodium depletion. After receiving propranolol orally for four to 14 weeks, repeat measurements were obtained under identical conditions of sodium intake. During normal sodium intake, propranolol therapy was associated with a decrease in plasma renin activity, a variable tendency to an increase in body weight and plasma volume, and a decrease in mean arterial pressure of 5 mm Hg (NS). During sodium restriction, blood pressure was decreased significantly from that observed during normal sodium intake and propranolol added a further significant decrease of 8 mm Hg (P less than .01). Blood pressure reductions obtained with sodium depletion and acute diuretic therapy were approximately the same with or without propranolol. The increase in plasma renin activity expected with sodium depletion and diuretic therapy was not blunted by propranolol.
12名高血压患者在正常钠摄入期和急性钠耗竭期测量了体重、血压、血浆肾素活性和血浆容量。口服普萘洛尔4至14周后，在相同的钠摄入条件下进行了重复测量。在正常钠摄入期间，普萘洛尔治疗与血浆肾素活性降低、体重和血浆容量增加的可变趋势以及平均动脉压降低5 mmHg（无统计学意义）相关。在钠限制期间，血压较正常钠摄入期显著降低，普萘洛尔进一步使血压显著降低8 mmHg（P小于0.01）。无论有无普萘洛尔，钠耗竭和急性利尿治疗所获得的血压降低大致相同。普萘洛尔并未抑制钠耗竭和利尿治疗所预期的血浆肾素活性增加。
