Reid D D, Hamilton P J, McCartney P, Rose G, Jarrett R J, Keen H
Lancet. 1976 Nov 6;2(7993):979-84. doi: 10.1016/s0140-6736(76)90830-8.
A five-year follow-up of 18 403 male British civil servants between the age of 40 and 64, who had been the subject of an earlier clinical survey found 277 deaths from coronary heart-disease (C.H.D.). After adjusting for age, current cigarette smoking, systolic and diastolic blood-pressure, and blood-cholesterol were shown to be related to both the prevalence of one or more indices of cardiac ischaemia and to the risk of cardiac death. Neither blood-glucose two hours after a 50 g load nor weight/height showed any such simple linear association with mortality. Multivariate analysis confirmed that the main risk factors were independently related to cardiac morbidity and mortality. Irrespective of blood-pressure or plasma-cholesterol, current cigarette smokers thus had a higher risk of C.H.D. death than those not smoking cigarettes.
对18403名年龄在40至64岁之间的英国男性公务员进行了为期五年的随访，这些人曾是早期临床调查的对象，结果发现有277人死于冠心病（C.H.D.）。在对年龄、当前吸烟情况、收缩压和舒张压以及血胆固醇进行调整后，发现这些因素与一种或多种心肌缺血指标的患病率以及心脏死亡风险均有关联。50克负荷后两小时的血糖水平以及体重/身高与死亡率均未显示出任何此类简单的线性关联。多变量分析证实，主要风险因素与心脏发病率和死亡率独立相关。因此，无论血压或血浆胆固醇水平如何，当前吸烟者死于冠心病的风险均高于不吸烟者。
