Egg D
Pharmacol Res Commun. 1983 Sep;15(8):709-17. doi: 10.1016/s0031-6989(83)80001-0.
We have studied the influence of a polysulfated glycosaminoglycan (Arteparon) in comparison with indomethacin and piroxicam on the synthesis of prostaglandin E2 in Chinese hamster ovary cell cultures (CHO). The two non-steroidal anti-inflammatory drugs (NSAD) were found to be strong inhibitors of prostaglandin E2 (PGE2) synthesis. The inhibition was found to be dose-dependent. Arteparon, an antidegenerative drug for the treatment of osteoarthritis, was also found to inhibit PGE2 synthesis in the CHO cell cultures. The inhibition was not as strong as that of the NSAD and no correlation between the concentration of Arteparon and the inhibition of PGE2 synthesis could be demonstrated.
我们研究了一种多硫酸化糖胺聚糖（阿特帕龙）与吲哚美辛和吡罗昔康相比，对中国仓鼠卵巢细胞培养物（CHO）中前列腺素E2合成的影响。发现这两种非甾体抗炎药（NSAD）是前列腺素E2（PGE2）合成的强效抑制剂。这种抑制作用呈剂量依赖性。阿特帕龙是一种用于治疗骨关节炎的抗退变药物，也被发现在CHO细胞培养物中抑制PGE2合成。其抑制作用不如NSAD强，且无法证明阿特帕龙浓度与PGE2合成抑制之间存在相关性。
