Schmidt J B, Spona J
Z Hautkr. 1983 Sep 1;58(17):1228-41.
The following paper presents the results of treatment of premenstrual acne with an estriol containing ointment. The mode of action of this therapy is discussed. Evaluations of serum-HPRL at regular intervals served as parameter for a possible systemic estrogen effect. A central estrogen stimulation could not be proved. For documentation of possible therapeutic effects, we performed thin-layer chromatographic sebum-determinations from treated as well as untreated areas. The same technique could give us information about the working mechanism of external estrogen treatment in telling us possible parallelisms in the course of the lipid values during therapy. The findings confirm the local efficacy of the estriol-ointment. Clinical results ranged between good and excellent in 8 out of 12 patients. In addition the number of skin lesions decreased, and the skin itself looked "improved". This form of therapy may be a possible alternative to systemic hormone therapy or a good supply in a combination therapy.
以下论文介绍了使用含雌三醇软膏治疗经前痤疮的结果。讨论了该疗法的作用方式。定期评估血清高泌乳素水平作为可能的全身雌激素效应的参数。未证实存在中枢雌激素刺激。为记录可能的治疗效果，我们对治疗部位和未治疗部位进行了薄层色谱皮脂测定。同样的技术可以通过告诉我们治疗期间脂质值变化过程中可能的平行关系，为我们提供有关外用雌激素治疗作用机制的信息。研究结果证实了雌三醇软膏的局部疗效。12名患者中有8名临床结果为良好至优秀。此外，皮肤损害数量减少，皮肤本身看起来“有所改善”。这种治疗形式可能是全身激素治疗的一种替代方案，或者是联合治疗中的一种良好补充。
